NOT KNOWN FACTS ABOUT CONOLIDINE

A new review demonstrates that the compound conolidine, present in the pinwheel flower, only binds to 1 individual scavenger receptor."We confirmed that conolidine binds towards the newly discovered opioid receptor ACKR3, when demonstrating no affinity for the other 4 classical opioid receptors. By doing this, conolidine blocks ACKR3 and prevents i

The first asymmetric total synthesis of conolidine was produced by Micalizio and coworkers in 2011.[two] This artificial route will allow entry to possibly enantiomer (mirror picture) of conolidine by using an early enzymatic resolution."We confirmed that conolidine binds towards the recently identified opioid receptor ACKR3, when exhibiting no aff